FZR1 polyclonal, anti-human, mouse
€388.00
In stock
SKU
BS7791
Background:
Fizzy-related protein, known as fzr, is a conserved eukaryotic gene that has been recently identified as a 7WD domain family member and is implicated in cell cycle regulation of Drosophila and yeast. Retroviral overexpression of fzr in B-lymphoma cells reduces tumor formation. Fzr overexpression increases B-lymphoma cell susceptibility to natural killer cell (NK) cytotoxicity. Fzr has been implicated in a new category of genes which suppress B-cell tumorigenesis. Current research suggests a novel role for fzr in the target cell interaction with NK cells. Fzr also negatively regulates the levels of cyclins A, B and B3. Loss of fzr causes progression through an extra division cycle in the epidermis and inhibition of endoreduplication in the salivary gland, in addition to failure of cyclin removal. Conversely, premature fzr overexpression downregulates mitotic cyclins, inhibits mitosis and transforms mitotic cycles into endoreduplication cycles.
Alternative Name:
CDC20 like 1b, CDC20 like protein 1, CDC20-like protein 1, CDC20C, CDH1, Cdh1/Hct1 homolog, Fizzy related protein 1, Fizzy related protein, Fizzy related protein homolog, Fizzy-related protein homolog, Fizzy/cell division cycle 20 related 1, FYR, FZR 1, FZR 2, Fzr, FZR_HUMAN, Fzr1, Fzr1 protein, FZR2, HCDH 1, HCDH, hCDH1, KIAA1242,
Application Dilution: WB: 1:500~1:2000, IHC/IF: 1:50~1:200
Specificity: FZR1 polyclonal antibody detects endogenous levels of FZR1 protein.
Immunogen:
Recombinant full length Human FZR1.
MW: ~ 55 kDa
Swis Prot.: Q9UM11
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Fizzy-related protein, known as fzr, is a conserved eukaryotic gene that has been recently identified as a 7WD domain family member and is implicated in cell cycle regulation of Drosophila and yeast. Retroviral overexpression of fzr in B-lymphoma cells reduces tumor formation. Fzr overexpression increases B-lymphoma cell susceptibility to natural killer cell (NK) cytotoxicity. Fzr has been implicated in a new category of genes which suppress B-cell tumorigenesis. Current research suggests a novel role for fzr in the target cell interaction with NK cells. Fzr also negatively regulates the levels of cyclins A, B and B3. Loss of fzr causes progression through an extra division cycle in the epidermis and inhibition of endoreduplication in the salivary gland, in addition to failure of cyclin removal. Conversely, premature fzr overexpression downregulates mitotic cyclins, inhibits mitosis and transforms mitotic cycles into endoreduplication cycles.
Alternative Name:
CDC20 like 1b, CDC20 like protein 1, CDC20-like protein 1, CDC20C, CDH1, Cdh1/Hct1 homolog, Fizzy related protein 1, Fizzy related protein, Fizzy related protein homolog, Fizzy-related protein homolog, Fizzy/cell division cycle 20 related 1, FYR, FZR 1, FZR 2, Fzr, FZR_HUMAN, Fzr1, Fzr1 protein, FZR2, HCDH 1, HCDH, hCDH1, KIAA1242,
Application Dilution: WB: 1:500~1:2000, IHC/IF: 1:50~1:200
Specificity: FZR1 polyclonal antibody detects endogenous levels of FZR1 protein.
Immunogen:
Recombinant full length Human FZR1.
MW: ~ 55 kDa
Swis Prot.: Q9UM11
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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