GABA A Receptor α5 polyclonal, anti-human, mouse, rat

Background:
GAD-65 and GAD-67, glutamate decarboxylases, function to catalyze the production of GABA (gamma-aminobutyric acid). In the central nervous system GABA functions as the main inhibitory transmitter by increasing a Cl- conductance that inhibits neuronal firing. GABA has been shown to activate both ionotropic (GABAA) and metabotropic (GABAB) receptors as well as a third class of receptors called GABAC. Both GABAA and GABAC are ligand-gated ion channels, however, they are structurally and functionally distinct. Members of the GABAA receptor family include GABAA Rα1-6, GABAA R β1-3, GABAA Rγ1-3, GABAA Rδ, GABAA Rε, GABAA Rρ1 and GABAA Rρ2. The GABAB family is composed of GABAB R1α and GABAB R1β. GABA transporters have also been identified and include GABA T-1, GABA T-2 and GABA T-3 (also designated GAT-1, -2, and -3). The GABA transporters function to terminate GABA action.

Alternative Name:
GABRA5, GAA 5, GAA5, GABA(A) receptor subunit alpha-5, GABRA 5, Gabra5, Gamma aminobutyric acid GABA A receptor alpha 5, Gamma aminobutyric acid GABA A receptor alpha 5 precursor, Gamma aminobutyric acid receptor alpha 5 subunit precursor GABA A receptor, Gamma-aminobutyric acid receptor subunit alpha-5, GBRA5, GC138184,

Application Dilution:
ICC/IF:1:50-1:200
IHC:1:50-1:200
WB:1:500

Specificity: GABA A Receptor α5 polyclonal antibody detects endogenous levels of GABA A Receptor α5 protein.

Immunogen:
Recombinant protein

MW: 52 kDa

Swiss-Prot: P31644(Human) Q8BHJ7(Mouse) P19969(Rat)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.