GABA B Receptor 2 polyclonal, anti-human, mouse, rat

Background:
In the central nervous system (CNS), gamma-aminobutyric acid (GABA) is the main main inhibitory neurotransmitter that functions to regulate neuronal firing. GABA exerts its effects through two different kinds of receptors: ionotropic receptors (GABAA R and GABAC R), which produce fast inhibitory signals, and metabotropic receptors (GABAB R), which produce slow inhibitory signals. The GABAB R receptor is a heterodimer that consists of two multi-pass membrane proteins, designated GABAB R1 and GABAB R2, both of which belong to the G protein-coupled receptor family and are highly expressed in brain tissue. Together, GABAB R1 and GABAB R2 play a crucial role in the fine-tuning of inhibitory synaptic transmissions and are implicated in slow wave sleep, muscle relaxation, hippocampal long-term potentiation and antinociception events. Both GABAB R1 and GABAB R2 are regulated by G proteins that have a variety of functions, including activation of potassium channels, inhibition of adenylyl cyclase (A cyclase) activity and modulation of inositol phospholipid hydrolysis.

Alternative Name:
GABA-B receptor 2, GABA-B-R2, GABA-BR2, GABABR2, Gb2, Gabbr2, Gm425, Gpr51, BcDNA:GH07312, CG6706, CT20836, D Gaba2, FLJ36928, G protein coupled receptor 51, G-protein coupled receptor 51, GAB B R2, GABA B R2, GABA B receptor 2, GABA-B receptor 2, GABA-B-R2, GABA-BR2, GABAB R2, GABABR 2, GABABR2, GABB R2, GABBR 2, Gabbr2, GABR2, Gamma aminobutyric acid B receptor 2, Gamma aminobutyric acid GABA B receptor 2, Gamma aminobutyric acid type B receptor subunit 2, Gamma-aminobutyric acid type B receptor subunit 2, Gb 2, Gb2, GH07312, GPR 51, GPR51, GPRC 3B, GPRC3B, HG 20, HG20, HRIHFB2099, Metabotropic GABA B receptor subtype 2, OTTHUMP00000021776, OTTHUMP00000063797, R2 SUBUNIT,

Application Dilution:
WB:1:500-1:1,000
IHC:1:50-1:200
FC:1:50-1:100
ICC:1:50-1:100

Specificity: GABA B Receptor 2 polyclonal antibody detects endogenous levels of GABA B Receptor 2 protein.

Immunogen:
Recombinant protein

MW: 106 kDa

Swiss-Prot: Q80T41(Mouse) O88871(Rat)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.