GABABR2 (Ser783) polyclonal, anti-human, mouse, bovine, dog, chicken

Protein Family: Receptors and Channels

Pathway and Disease: Nervous and Sensory Systems

Description:
Gamma-aminobutyric acid type B receptor subunit 1 (GABA-Receptor, R-2 subunit), together with the GABA-Receptor, R-1 subunit, forms a receptor for GABA. The activity of GABA-B-Receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulate phospholipase A2, activates potassium channels, inactivate voltage-dependent calcium-channels and modulate inositol phospholipids hydrolysis. The GABA-B-Receptor plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-Receptors inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA-B-Receptor decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. The GABA receptor has not only been implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception.

Alternate Names: Gamma-aminobutyric acid type B receptor subunit 2, GABA-B receptor 2, GABA-B-R2, GABA-BR2, GABABR2, Gb2, G-protein coupled receptor 51, Gabbr2, Gpr51

Application Notes: E: 1:1,000; WB: 1:1,000; IHC: 1:500; IF: 1:500

Accession No.: O88871

Antigen: KLH-conjugated synthetic phosphopeptide encompassing a sequence surrounding Ser783 of rat GABAB receptor, R2-subunit.

Format: Each vial contains 0.1 ml IgG in HEPES pH7.5, 150 mM NaCl, 0.01% BSA and 50% glycerol. Antibody was purified by immunogen affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.