GAD-67 polyclonal, anti-human, mouse, rat
€388.00
In stock
SKU
BS72024
Background:
GAD-65 and GAD-67 are members of the group II decarboxylase family of proteins and are responsible for catalyzing the rate limiting step in the production of GABA (γ-aminobutyric acid) from L-glutamic acid. Although both GADs are found in the brain, GAD-65 localizes to synaptic vesicle membranes in nerve terminals, while GAD-67 is distributed throughout the cell. GAD-67 is responsible for the basal levels of GABA synthesis. In the case of a heightened demand for GABA in neurotransmission, GAD-65 will transiently activate to assist in GABA production. The loss of GAD-65 is detrimental and can impair GABA neurotransmission, however the loss of GAD-67 is lethal. Due to alternative splicing, two isoforms exist for GAD-67: the predominant GAD-67 form and the minor GAD-25 form.
Alternative Name:
Glutamate decarboxylase 1, 67 kDa glutamic acid decarboxylase, GAD 67, Glutamate decarboxylase 67 kDa isoform, GAD1, GAD, GAD67, GAD-1, GAD 1
Application Dilution: WB: 1:500 - 1:2000
Specificity: GAD-67 polyclonal antibody detects endogenous levels of GAD-67 protein.
Immunogen:
Recombinant protein of human GAD1
MW: ~ 67 kDa
Swis Prot.: Q99259
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
GAD-65 and GAD-67 are members of the group II decarboxylase family of proteins and are responsible for catalyzing the rate limiting step in the production of GABA (γ-aminobutyric acid) from L-glutamic acid. Although both GADs are found in the brain, GAD-65 localizes to synaptic vesicle membranes in nerve terminals, while GAD-67 is distributed throughout the cell. GAD-67 is responsible for the basal levels of GABA synthesis. In the case of a heightened demand for GABA in neurotransmission, GAD-65 will transiently activate to assist in GABA production. The loss of GAD-65 is detrimental and can impair GABA neurotransmission, however the loss of GAD-67 is lethal. Due to alternative splicing, two isoforms exist for GAD-67: the predominant GAD-67 form and the minor GAD-25 form.
Alternative Name:
Glutamate decarboxylase 1, 67 kDa glutamic acid decarboxylase, GAD 67, Glutamate decarboxylase 67 kDa isoform, GAD1, GAD, GAD67, GAD-1, GAD 1
Application Dilution: WB: 1:500 - 1:2000
Specificity: GAD-67 polyclonal antibody detects endogenous levels of GAD-67 protein.
Immunogen:
Recombinant protein of human GAD1
MW: ~ 67 kDa
Swis Prot.: Q99259
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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