GAD1 antibody (clone 500000000000), anti-human
€435.00
In stock
SKU
AC-AT2144a
Catalog Number: AC-AT2144a
Size: 100 µg
Isotype: mouse IgG2a Kappa
Applications: WB
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Size: 100 µg
Isotype: mouse IgG2a Kappa
Applications: WB
Request Information AC-AT2144a">Request Information
Background:
This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures. Alternative splicing of this gene results in two products, the predominant 67-kD form and a less-frequent 25-kD form.
Other Names:
Glutamate decarboxylase 1, 67 kDa glutamic acid decarboxylase, GAD-67, Glutamate decarboxylase 67 kDa isoform, GAD1, GAD, GAD67
Antigen Type:
Recombinant Protein
Gene Name: GAD1 (HGNC:4092)
Gene ID: 2571
NCBI Accession: NP_000808.2;NP_038473.2
Primary Accession: Q99259
Other Accession: BC037780
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures. Alternative splicing of this gene results in two products, the predominant 67-kD form and a less-frequent 25-kD form.
Other Names:
Glutamate decarboxylase 1, 67 kDa glutamic acid decarboxylase, GAD-67, Glutamate decarboxylase 67 kDa isoform, GAD1, GAD, GAD67
Antigen Type:
Recombinant Protein
Gene Name: GAD1 (HGNC:4092)
Gene ID: 2571
NCBI Accession: NP_000808.2;NP_038473.2
Primary Accession: Q99259
Other Accession: BC037780
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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