GAD2 polyclonal, anti-human, mouse, rat

Background:
This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein.

Synonyms: GAD65

Cellular Location: Cell junction Cytoplasm Cytoplasmic side Cytoplasmic vesicle Golgi apparatus membrane Lipid-anchor Peripheral membrane protein cytosol presynaptic cell membrane synapse

Immunogen:
Recombinant protein of human GAD2

Gene Symbol: GAD2

Gene ID: 2572

Swiss prot: Q05329

Calculated MW: 65kDa

Recommended dilution:
WB 1:500-2000, IHC 1:50-200, IF 1:10-100,

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.