GADD 45γ (S123) polyclonal, anti-human, mouse, rat
€305.00
In stock
SKU
BS9140
Background:
Cell cycle progression is subject to arrest at G1 and G2 checkpoints in response to DNA damage, presumably to allow time for DNA repair prior to entry into S and M phase, respectively. The p53 tumor suppressor is required for one such G1 checkpoint and functions to upregulate expression of GADD 45 and p21. GADD 45 binds both Cdks and PCNA, a protein involved in DNA replication and repair. GADD 45 stimulates DNA excision repair in vitro and inhibits entry of cells into S phase. Thus, it has been suggested that GADD 45 may serve as a link between the p53-dependent cell cycle checkpoint and DNA repair. GADD 45-like proteins, GADD 45β and GADD 45γ, have been shown to be induced by environmental stresses. GADD 45β and GADD 45γ are thought to induce p38/JNK activation via MEKK4 activation.
Alternative Name:
CR6, Cytokine responsive protein CR6, Cytokine-responsive protein CR6, DDIT-2, DDIT2, DNA damage-inducible transcript 2 protein, GA45G, Gadd45g, Growth arrest and DNA damage inducible gamma, Growth arrest and DNA damage-inducible protein GADD45 gamma, GRP17,
Application Dilution: IHC: 1:50~1:200
Specificity: GADD 45γ (S123) polyclonal antibody detects endogenous levels of GADD 45γ protein.
Immunogen:
Synthetic peptide, corresponding to amino acids 101-150 of Human GADD 45γ.
MW: ~ 17 kDa
Swis Prot.: O95257
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Cell cycle progression is subject to arrest at G1 and G2 checkpoints in response to DNA damage, presumably to allow time for DNA repair prior to entry into S and M phase, respectively. The p53 tumor suppressor is required for one such G1 checkpoint and functions to upregulate expression of GADD 45 and p21. GADD 45 binds both Cdks and PCNA, a protein involved in DNA replication and repair. GADD 45 stimulates DNA excision repair in vitro and inhibits entry of cells into S phase. Thus, it has been suggested that GADD 45 may serve as a link between the p53-dependent cell cycle checkpoint and DNA repair. GADD 45-like proteins, GADD 45β and GADD 45γ, have been shown to be induced by environmental stresses. GADD 45β and GADD 45γ are thought to induce p38/JNK activation via MEKK4 activation.
Alternative Name:
CR6, Cytokine responsive protein CR6, Cytokine-responsive protein CR6, DDIT-2, DDIT2, DNA damage-inducible transcript 2 protein, GA45G, Gadd45g, Growth arrest and DNA damage inducible gamma, Growth arrest and DNA damage-inducible protein GADD45 gamma, GRP17,
Application Dilution: IHC: 1:50~1:200
Specificity: GADD 45γ (S123) polyclonal antibody detects endogenous levels of GADD 45γ protein.
Immunogen:
Synthetic peptide, corresponding to amino acids 101-150 of Human GADD 45γ.
MW: ~ 17 kDa
Swis Prot.: O95257
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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