GADD45A polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
Growth arrest and DNA-damage-inducible protein GADD45 alpha(GADD45A) is a protein that in humans is encoded by the GADD45A gene. This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. Papathanasiou et al.(1991) demonstrated that the GADD45 gene is located on 1p34-p12. Sequence analysis of human and hamster cDNA clones demonstrated that the gene has been highly conserved and encodes a novel 165-amino acid polypeptide. Northern blot analysis detected moderate expression of a 1.4-kb GADD45A transcript in heart, skeletal muscle, and kidney, with little or no expression in brain, placenta, lung, liver, and pancreas. Gadd45a promotes epigenetic gene activation by repair-mediated DNA demethylation.

Description:
Rabbit IgG polyclonal antibody for Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A) detection. Tested with WB in Human, Mouse, Rat.

Synonyms:
DDIT 1 antibody, DDIT-1 antibody, DDIT1 antibody, DNA damage inducible transcript 1 antibody, DNA damage-inducible transcript 1 protein antibody, GA45A_HUMAN antibody, GADD45 antibody, GADD45A antibody, Growth arrest and DNA damage inducible 45 alpha antibody, Growth arrest and DNA damage inducible alpha antibody, Growth arrest and DNA damage-inducible protein GADD45 alpha antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the C-terminus of human GADD45A(129-143aa NPHSSQWKDPALSQL), identical to the related mouse and rat sequences.A synthetic peptide corresponding to a sequence at the C-terminus of human GADD45A(129-143aa NPHSSQWKDPALSQL), identical to the related mouse and rat sequences.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, rat .
Predicted to work with: mouse.

Applications: WB

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.