GADD45A Polyclonal Antibody

Background:
This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The DNA damage-induced transcription of this gene is mediated by both p53-dependent and -independent mechanisms. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Research Area: Cancer, Epigenetics and Nuclear Signaling

Synonyms:
DDIT1, GADD45, GADD45A

Immunogen: Recombinant fusion protein of human GADD45A (NP_001915.1).

Swissprot: P24522
Gene ID: 1647

Calculated MW: 14 kDa/18 kDa
Observed MW: 20 kDa/25 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:500-1:2000 IHC 1:50-1:200 IF 1:50-1:200"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.