GADD45B polyclonal, anti-human, mouse, rat
€305.00
In stock
SKU
BS60080
Background:
Cellcycle progression issubject to arrest at G1 and G2 checkpointsin response to DNA damage, presumablyto allow time for DNA repair prior to entryinto S andMphase, respectively. The p53 tumorsuppressor isrequired for one such G1 checkpoint and functionsto upregulate expression of GADD 45 and p21. GADD 45 binds both Cdks and PCNA, a protein involved in DNA replication and repair. GADD 45 stimulates DNA excision repair in vitro and inhibits entry ofcellsinto S phase. Thus, it has been suggested that GADD 45 mayserve as a link between the p53-dependentcellcycle checkpoint and DNA repair. GADD 45-like proteins, GADD 45β and GADD 45γ, have been shown to be induced by environmentalstresses. GADD 45β and GADD 45γ are thought to induce p38/JNK activation via MEKK4 activation.
Alternative Name:
Growth arrest and DNA damage-inducible protein GADD45 beta, Myeloid differentiation primary response protein MyD118, Negative growth regulatory protein MyD118, GADD45B, MYD118
Application Dilution: WB: 1:500~1:1000
Specificity: GADD45B polyclonal antibody detects endogenous levels of GADD45B protein.
Immunogen:
A synthetic peptide corresponding to residues in Human GADD45B.
MW: ~ 25 kDa
Swis Prot.: O75293
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Cellcycle progression issubject to arrest at G1 and G2 checkpointsin response to DNA damage, presumablyto allow time for DNA repair prior to entryinto S andMphase, respectively. The p53 tumorsuppressor isrequired for one such G1 checkpoint and functionsto upregulate expression of GADD 45 and p21. GADD 45 binds both Cdks and PCNA, a protein involved in DNA replication and repair. GADD 45 stimulates DNA excision repair in vitro and inhibits entry ofcellsinto S phase. Thus, it has been suggested that GADD 45 mayserve as a link between the p53-dependentcellcycle checkpoint and DNA repair. GADD 45-like proteins, GADD 45β and GADD 45γ, have been shown to be induced by environmentalstresses. GADD 45β and GADD 45γ are thought to induce p38/JNK activation via MEKK4 activation.
Alternative Name:
Growth arrest and DNA damage-inducible protein GADD45 beta, Myeloid differentiation primary response protein MyD118, Negative growth regulatory protein MyD118, GADD45B, MYD118
Application Dilution: WB: 1:500~1:1000
Specificity: GADD45B polyclonal antibody detects endogenous levels of GADD45B protein.
Immunogen:
A synthetic peptide corresponding to residues in Human GADD45B.
MW: ~ 25 kDa
Swis Prot.: O75293
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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