GADD45B Polyclonal Antibody

Background:
This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The genes in this group respond to environmental stresses by mediating activation of the p38/JNK pathway. This activation is mediated via their proteins binding and activating MTK1/MEKK4 kinase, which is an upstream activator of both p38 and JNK MAPKs. The function of these genes or their protein products is involved in the regulation of growth and apoptosis. These genes are regulated by different mechanisms, but they are often coordinately expressed and can function cooperatively in inhibiting cell growth.

Research Area: Cancer, Cell Biology, Epigenetics and Nuclear Signaling, Immunology, Signal Transduction

Synonyms:
GA45B, GADD45 Beta, Gadd45b, GADD45BETA, Growth arrest and DNA damage inducible 45 beta, Growth arrest and DNA damage inducible beta, Growth arrest and DNA damage-inducible gene GADD45, beta, Growth arrest and DNA damage-inducible protein GADD45 beta, Growth arrest and DNA-damage-inducible protein GADD45 beta, MY118, MYD118, MYD118, mouse, homolog of, Myeloid differentiation primary response gene, Myeloid differentiation primary response protein MyD118, Negative growth regulatory protein MyD118, Negative growth-regulatory protein MyD118

Immunogen: Recombinant protein of human GADD45B

Swissprot: O75293
Gene Accession: BC113466

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.6 mg/mL
Dilution: IHC 1:50-1:200

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-8776/sc-8775/sc-30368/sc-30369/sc-33172/sc-133606