GAPDH (clone 8G4), anti-human

Background:
Mouse Monoclonal

Decription:
Multiple roles for glyceraldehyde-3-phosphate dehydrogenase (GAPDH) have been recently appreciated. GAPDH is found in the particulate fractions, such as the nucleus, the mitochondria, and the small vesicular fractions. GAPDH gene expression is specifically increased during programmed neuronal cell death. When cells are exposed to various stressors, dynamic subcellular re-distribution of GAPDH occurs. GAPDH is also involved in various diseases, especially neurodegenerative disorders and cancers. As a membrane protein, GAPDH functions in endocytosis; in the cytoplasm, it is involved in the translational control of gene expression; in the nucleus, it functions in nuclear tRNA export, in DNA replication, and in DNA repair.

Synonyms: G3PD, GAPD, MGC88685, Glyceraldehyde-3-phosphate dehydrogenase, GAPDH, Glyceraldehyde-3-phosphate dehydrogenase 38 kDa BFA-dependent ADP-ribosylation substrate, Aging-associated gene 9 protein, BARS-38, cb609, EC 1.2.1.12, G3PDH, OCAS, p38 component, Glyceraldehyde 3 phosphate dehydrogenase, KNC-NDS6, MGC102544, MGC102546, MGC103190, MGC103191, MGC105239, MGC127711, OCT1 coactivator in S phase, 38-KD component, OTTHUMP00000174431, OTTHUMP00000174432, wu:fb33a10.

Clone: 8G4. Anti-human GAPDH mAb, clone 8G4, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human GAPDH protein.

Isotype: IgG2b, k

Immunogen: Recombinant human GAPDH (1-335aa) purified from E.coli

Reactivity: human

Form: Purified, in Phosphate-Buffered Saline (pH 7.4) with 0.1% Sodium Azide

Applications: ELISA, WB, Immunofluorescence

Working Dilution: Optimal dilution should be performed by user.

NCBI Nr.: NP_002037

Concentration: 0.1 mg/ml

Storage: Can be stored at +4C. For long term storage, aliquot and store at -20C. Avoid repeated freezing and thawing cycles.