cIAP2 monoclonal, anti-human
€470.00
In stock
SKU
AC-AP52771
Catalog Number: AC-AP55121
Size: 100 µl
Host: Rabbit
Applications: WB, IHC-P, IHC-F, IF, ICC, E
Datasheet
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Size: 100 µl
Host: Rabbit
Applications: WB, IHC-P, IHC-F, IF, ICC, E
Datasheet
Request Information
Background:
Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin- protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin- protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, IKBKE, TRAF1, and BCL10. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase- independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8.
Other Names:
AIP 1;AIP1;API 2;API2;API2;Apoptosis inhibitor 2;Baculoviral IAP repeat containing 3;Baculoviral IAP repeat containing protein 3;Baculoviral IAP repeat-containing protein 3;BIRC 3;BIRC3;BIRC3;BIRC3_HUMAN;C IAP2;C-IAP2;CIAP 2;CIAP 2;CIAP2;HAIP 1;HAIP1;HAIP1; HIAP 1;HIAP-1;HIAP1;IAP homolog C;IAP-1;Inhibitor of apoptosis protein 1;Inhibitor of apoptosis protein 1;MALT 2;MALT2;Mammalian IAP homolog C;MIHC;MIHC;RING finger protein 49;RNF49;TNFR2 TRAF signaling complex protein 1;TNFR2 TRAF signalling complex protein;TNFR2-TRAF-signaling complex protein 1.
Antigen Type: Recombinant Protein
Antigen Type: BIRC3
Gene ID: 330
Primary Accession: Q13489
Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin- protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin- protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, IKBKE, TRAF1, and BCL10. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase- independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8.
Other Names:
AIP 1;AIP1;API 2;API2;API2;Apoptosis inhibitor 2;Baculoviral IAP repeat containing 3;Baculoviral IAP repeat containing protein 3;Baculoviral IAP repeat-containing protein 3;BIRC 3;BIRC3;BIRC3;BIRC3_HUMAN;C IAP2;C-IAP2;CIAP 2;CIAP 2;CIAP2;HAIP 1;HAIP1;HAIP1; HIAP 1;HIAP-1;HIAP1;IAP homolog C;IAP-1;Inhibitor of apoptosis protein 1;Inhibitor of apoptosis protein 1;MALT 2;MALT2;Mammalian IAP homolog C;MIHC;MIHC;RING finger protein 49;RNF49;TNFR2 TRAF signaling complex protein 1;TNFR2 TRAF signalling complex protein;TNFR2-TRAF-signaling complex protein 1.
Antigen Type: Recombinant Protein
Antigen Type: BIRC3
Gene ID: 330
Primary Accession: Q13489
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