Gastrin/Cholecystokinin (CCK) polyclonal, anti-human, rat, cat, pig

Quantity: 100 µl

Background:
Cholecystokinin is a brain/gut peptide. In the gut, it induces the release of pancreatic enzymes and the contraction of the gallbladder. In the brain, its physiologic role is unclear. The cholecystokinin pro-hormone is processed by endo- and exo-proteolytic cleavages. Two transcript variants encoding the same protein have been found for this gene.

Synonyms:
CCK

Isotype: Rabbit Polyclonal

Immunogen:
Synthetic human gastrin 1-34

Form: Serum containing 0.1% sodium azide

Specificity:
The antibody can be used for the diagnosis of gastrin-producing tumors which are mainly found in the pancreas and occasionally in the stomach and the duodenum. Absorption with 10-100 ?g gastrin 1-34. gastrin 1-17, CCK 8 and CCK 4 per ml antiserum abolishes the staining, while CCK 10-20 does not.

Reactivity: human, rat, cat, pig

Applications: Immunofluorescence, Immunohistochemistry, suitable for frozen and paraffin-embedded tissue, no proteolytic treatment

Working DIlution: 1:15 - 1:25 using FITC

Positive Control:
Rat antrum

Storage: 2-8C for immediate use, or at -20C (aliquot)

References:
- Lönroth H et al. (1990) Gut 31: 383-388