GAT-1 polyclonal, anti-mouse, rat

Protein Family: Receptors and Channels

Pathway and Disease: Nervous and Sensory Systems

Description:
Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a chloride channel associated with the GABAA receptor (GABAA-R) subtype. GABA plasma membrane transporters (GATs) influence synaptic neurotransmission by high-affinity uptake and release of GABA. To date, four distinct GABA transporters have been identified: GAT-1, GAT-2, GAT-3, and BGT-1. GAT-1, the most abundant of the transporters, is found predominantly in neurons, but also in some specialized glia. GAT-1 is thought to play a key role in epileptogenesis.

Alternate Names: Sodium- and chloride-dependent GABA transporter 1, GAT-1, Solute carrier family 6 member 1, Slc6a1, Gabt1, Gat-1, Gat1

Application Notes: E: 1:500-1:1,000; WB: 1:1,000; IHC: 1:100-1:200

Accession No.: P23978

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of rat GABA transporter (GAT) 1.

Format: Each vial contains 0.1 ml IgG in HEPES (pH7.5), 0.01% BSA, with 50% glycerol. Antibody was purified by immunogen affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.