GATA3 (clone 1A10D1), anti-human
€478.00
In stock
SKU
252756
Protein Family: Transcription Factors
Pathway and Disease: Transcription
Description:
GATA3 (GATA binding protein 3) is an enhancer-binding protein containing a zinc finger domain. The genes for all 4 subunits of the T-cell antigen receptor (alpha, beta, gamma and delta) are controlled by distinct enhancers and their enhancer-binding proteins. A common TCR regulatory element was identified by demonstrating binding of the enhancer-binding protein GATA3 to the enhancer elements of all 4 TCR genes. GATA3 mRNA was demonstrated by Northern blot analysis in T cells but not in B cells, macrophages, or HeLa cell lines. GATA3 is abundantly expressed in the T-lymphocyte lineage and is thought to participate in T-cell receptor gene activation through binding to enhancers. The human gene comprises 6 exons distributed over 17 kb of DNA. Its 2 zinc fingers are encoded by 2 separate exons highly conserved with those of GATA1, but no other structural homologies between the 2 genes could be found.
Alternate Names: HDR, Trans-acting T-cell-specific transcription factor GATA-3 , GATA-binding factor 3
Application Notes: WB: 1:500-1:2000
Accession No.: P23771
Antigen: Purified recombinant fragment of GATA3(aa175-388) expressed in E. coli.
Format: Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
Pathway and Disease: Transcription
Description:
GATA3 (GATA binding protein 3) is an enhancer-binding protein containing a zinc finger domain. The genes for all 4 subunits of the T-cell antigen receptor (alpha, beta, gamma and delta) are controlled by distinct enhancers and their enhancer-binding proteins. A common TCR regulatory element was identified by demonstrating binding of the enhancer-binding protein GATA3 to the enhancer elements of all 4 TCR genes. GATA3 mRNA was demonstrated by Northern blot analysis in T cells but not in B cells, macrophages, or HeLa cell lines. GATA3 is abundantly expressed in the T-lymphocyte lineage and is thought to participate in T-cell receptor gene activation through binding to enhancers. The human gene comprises 6 exons distributed over 17 kb of DNA. Its 2 zinc fingers are encoded by 2 separate exons highly conserved with those of GATA1, but no other structural homologies between the 2 genes could be found.
Alternate Names: HDR, Trans-acting T-cell-specific transcription factor GATA-3 , GATA-binding factor 3
Application Notes: WB: 1:500-1:2000
Accession No.: P23771
Antigen: Purified recombinant fragment of GATA3(aa175-388) expressed in E. coli.
Format: Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
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