GBL Antibody (C-term) Blocking Peptide
€363.00
In stock
SKU
AC-BP8200b
Background:
G锟淟 (G protein beta protein subunit-like) is a member of a signaling pathway that regulates mammalian cell growth in response to the presence of nutrients and growth factors. It binds to the kinase domain of TOR (Target of rapamycin, also known as mTOR), an evolutionarily conserved serine/threonine kinase that regulates cell growth and cell cycle through its ability to integrate signals from nutrient levels and growth factors. Rapamycin inhibits TOR resulting in reduced cell growth and reduced rates of cell cycle and cell proliferation. TOR is normally associated with G锟淟 and an additional regulatory protein RAPTOR, allowing TOR to control protein biosynthesis. The binding of G锟淟 to TOR stimulates TOR's kinase activity towards downstream proteins such as RPS6K (ribosomal protein S6 kinase) and the translation factor 4E-BP1 which leads to increased protein translation and cell growth.
Other Names:
Target of rapamycin complex subunit LST8, TORC subunit LST8, G protein beta subunit-like, Gable, Protein GbetaL, Mammalian lethal with SEC13 protein 8, mLST8, MLST8, GBL, LST8
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP8200b was selected from the C-term region of human GBL. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: MLST8 {ECO:0000303|PubMed:34741373, ECO:0000312|HGNC:HGNC:24825}
Gene ID: 64223
Primary Accession: Q9BVC4
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
G锟淟 (G protein beta protein subunit-like) is a member of a signaling pathway that regulates mammalian cell growth in response to the presence of nutrients and growth factors. It binds to the kinase domain of TOR (Target of rapamycin, also known as mTOR), an evolutionarily conserved serine/threonine kinase that regulates cell growth and cell cycle through its ability to integrate signals from nutrient levels and growth factors. Rapamycin inhibits TOR resulting in reduced cell growth and reduced rates of cell cycle and cell proliferation. TOR is normally associated with G锟淟 and an additional regulatory protein RAPTOR, allowing TOR to control protein biosynthesis. The binding of G锟淟 to TOR stimulates TOR's kinase activity towards downstream proteins such as RPS6K (ribosomal protein S6 kinase) and the translation factor 4E-BP1 which leads to increased protein translation and cell growth.
Other Names:
Target of rapamycin complex subunit LST8, TORC subunit LST8, G protein beta subunit-like, Gable, Protein GbetaL, Mammalian lethal with SEC13 protein 8, mLST8, MLST8, GBL, LST8
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP8200b was selected from the C-term region of human GBL. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: MLST8 {ECO:0000303|PubMed:34741373, ECO:0000312|HGNC:HGNC:24825}
Gene ID: 64223
Primary Accession: Q9BVC4
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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