GBP1 polyclonal, anti-human

Quantity: 100 µg

Background:
Interferons induce a large number of genes in their target cells, including those coding for guanylate-binding proteins(GBPs). GBPs, such as GBP1, are characterized by their ability to specifically bind guanine nucleotides(GMP, GDP, and GTP) and are distinguished from the GTP-binding proteins by the presence of 2 binding motifs rather than 3. The 593-amino acid GBP1 protein shares 77% and 88% identity with GBP2 and GBP3, respectively. All GBPs, including GBP1, have a conserved N-terminal globular GTP-binding domain containing 2 consensus sequences and a third T(L/V)RD sequence not found in other GTPases. The GBP1 gene to the GBP gene cluster on chromosome 1p22.2. It is located telomeric to GBP2 and centromeric to GBP3. High expression of GBP1, GBP2, and GBP3 are in endothelial cells after stimulation with IFNG, TNF, or IL1B .

Description:
Rabbit IgG polyclonal antibody for Interferon-induced guanylate-binding protein 1 (GBP1) detection. Tested with WB in Human.

Synonyms:
GBP 1 antibody, GBP-1 antibody, GBP1 antibody, GBP1_HUMAN antibody, GTP binding protein 1 antibody, GTP-binding protein 1 antibody, Guanine nucleotide binding protein 1 antibody, Guanine nucleotide-binding protein 1 antibody, Guanylate binding protein 1 antibody, Guanylate binding protein 1 interferon inducible 67kDa antibody, Guanylate binding protein 1 interferon inducible antibody, HuGBP 1 antibody, HuGBP-1 antibody, HuGBP1 antibody, Interferon induced guanylate binding protein 1 antibody, Interferon-induced guanylate-binding protein 1 antibody, OTTHUMP00000012352 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the C-terminus of human GBP1(566-589aa QKESRIMKNEIQDLQTKMRRRKAC).

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human

Applications: WB

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.