GCA antibody (clone 2F5), anti-human

Background:
This gene product, grancalcin, is a calcium-binding protein abundant in neutrophils and macrophages. It belongs to the penta-EF-hand subfamily of proteins which includes sorcin, calpain, and ALG-2. Grancalcin localization is dependent upon calcium and magnesium. In the absence of divalent cation, grancalcin localizes to the cytosolic fraction; with magnesium alone, it partitions with the granule fraction; and in the presence of magnesium and calcium, it associates with both the granule and membrane fractions, suggesting a role for grancalcin in granule-membrane fusion and degranulation.

Other Names:
Grancalcin, GCA, GCL

Antigen Type:
Recombinant Protein

Gene Name: GCA
Gene ID: 25801
NCBI Accession: NP_036330.1
Primary Accession: P28676
Other Accession: BC005214
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .