GCAP3 Antibody (N-term) Blocking Peptide

Background:
GCAP3 stimulates guanylyl cyclase 1 (GC1) and GC2 when free calcium ion concentration is low and inhibits guanylyl cyclases when free calcium ion concentration is elevated This Ca(2+) sensitive regulation of guanylyl cyclase (GC) is a key event in recovery of the dark state of rod photoreceptors following light exposure. GCAP3 contains 4 EF-hand calcium-binding domains and is expressed in the retina.

Other Names:
Guanylyl cyclase-activating protein 3, GCAP 3, Guanylate cyclase activator 1C, GUCA1C, GCAP3

Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP1569a was selected from the N-term region of human GCAP3 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.

Gene Name: GUCA1C

Gene ID: 9626
Primary Accession: O95843
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.