GCH1 antibody (clone 4A12), anti-human
€435.00
In stock
SKU
AC-AT2174a
Catalog Number: AC-AT2174a
Size: 100 µg
Isotype: mouse IgG2a Kappa
Applications: WB, IHC, IP, E
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Size: 100 µg
Isotype: mouse IgG2a Kappa
Applications: WB, IHC, IP, E
Request Information AC-AT2174a">Request Information
Background:
This gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin (BH4) biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described; however, not all variants give rise to a functional enzyme.
Other Names:
GTP cyclohydrolase 1, GTP cyclohydrolase I, GTP-CH-I, GCH1, DYT5, GCH
Antigen Type:
Recombinant Protein
Gene Name: GCH1
Gene ID: 2643
NCBI Accession: NP_000152.1;NP_001019195.1;NP_001019241.1;NP_001019242.1
Primary Accession: P30793
Other Accession: NM_000161
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
This gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin (BH4) biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described; however, not all variants give rise to a functional enzyme.
Other Names:
GTP cyclohydrolase 1, GTP cyclohydrolase I, GTP-CH-I, GCH1, DYT5, GCH
Antigen Type:
Recombinant Protein
Gene Name: GCH1
Gene ID: 2643
NCBI Accession: NP_000152.1;NP_001019195.1;NP_001019241.1;NP_001019242.1
Primary Accession: P30793
Other Accession: NM_000161
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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