GCH1 polyclonal, anti-human

Background:
This gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin (BH4) biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described; however, not all variants give rise to a functional enzyme.

Synonyms: GCH, DYT5, DYT14, DYT5a, GTPCH1, HPABH4B, GTP-CH-1

Cellular Location: Cytoplasm

Immunogen:
A synthetic peptide of human GCH1

Gene Symbol: GCH1

Gene ID: 2643

Swiss prot: P30793

Calculated MW: 28kDa

Recommended dilution:
WB 1:200-1000, IHC 1:5-20,

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.