GCLC polyclonal (N-term), anti-human
€0.00
In stock
SKU
AC-AP11943a
Catalog Number: AC-AP11943a
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB31687
Applications: FC, IF, IHC-P, WB
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB31687
Applications: FC, IF, IHC-P, WB
Datasheet
Request Information
Background:
Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate-limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. This locus encodes the catalytic subunit, while the regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Mutations at this locus have been associated with hemolytic anemia due to deficiency of gamma-glutamylcysteine synthetase and susceptibility to myocardial infarction.
Other Names:
Glutamate--cysteine ligase catalytic subunit, GCS heavy chain, Gamma-ECS, Gamma-glutamylcysteine synthetase, GCLC, GLCL, GLCLC
Target/Specificity:
This GCLC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human GCLC.
Antigen Region:
1-30
Antigen Type: Synthetic Peptide
Gene Name: GCLC (HGNC:4311)
Gene ID: 2729
Primary Accession: P48506
NCBI Accession: NP_001184044.1;NP_001489.1
Other Accession: NP_001489.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate-limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. This locus encodes the catalytic subunit, while the regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Mutations at this locus have been associated with hemolytic anemia due to deficiency of gamma-glutamylcysteine synthetase and susceptibility to myocardial infarction.
Other Names:
Glutamate--cysteine ligase catalytic subunit, GCS heavy chain, Gamma-ECS, Gamma-glutamylcysteine synthetase, GCLC, GLCL, GLCLC
Target/Specificity:
This GCLC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human GCLC.
Antigen Region:
1-30
Antigen Type: Synthetic Peptide
Gene Name: GCLC (HGNC:4311)
Gene ID: 2729
Primary Accession: P48506
NCBI Accession: NP_001184044.1;NP_001489.1
Other Accession: NP_001489.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
| Is Featured? | No |
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