GDF15 polyclonal, anti-human, mouse

Background:
Regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses. Binds to its receptor, GFRAL, and activates GFRAL-expressing neurons localized in the area postrema and nucleus tractus solitarius of the brainstem. It then triggers the activation of neurons localized within the parabrachial nucleus and central amygdala, which contitutes part of the emergency circuit that shapes feeding responses to stressful conditions.

Synonyms: Growth/differentiation factor 15, GDF-15, MIC-1, MIC-1, NRG-1

Cellular Location: Secreted

Immunogen:
Recombinant protein of human GDF15

Gene Symbol: GDF15

Swiss prot: Q99988

Calculated MW: 34kDa

Recommended dilution:
WB 1:1000-5000

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.