GDNF Polyclonal Antibody

Background:
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The recombinant form of this protein, a highly conserved neurotrophic factor, was shown to promote the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. This protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. Mutations in this gene may be associated with Hirschsprung disease and Tourette syndrome. This gene encodes multiple protein isoforms that may undergo similar proteolytic processing.

Research Area: Neuroscience,Developmental Biology

Synonyms:
Astrocyte derived trophic factor, Astrocyte derived trophic factor 1, Astrocyte-derived trophic factor, ATF 1, ATF 2, Atf, ATF1, ATF2, gdnf, GDNF, Glial cell derived neurotrophic factor, Glial Cell Line Derived Neurotrophic Factor, Glial cell line-derived neurotrophic factor, Glial derived neurotrophic factor, HFB1 GDNF, hGDNF, HSCR3

Immunogen: KLH conjugated Synthetic peptide corresponding to mouse GDNF

Swissprot: Q07731,P48540

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 1% BSA and 50% glycerol, pH7.4

Concentration: 80 μg/mL
Dilution: IHC 1:100-1:500

Storage:
Store at -20°C. Avoid freeze / thaw cycles.