GEMIN7 N-terminal region polyclonal, anti-human, mouse, rat, horse, bovine, guinea pig, dog

Background:
The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus.

Other Names:
Gem-associated protein 7, Gemin-7, SIP3, GEMIN7

Immunogen:
The immunogen for Anti-GEMIN7 antibody is: synthetic peptide directed towards the N-terminal region of Human GEMIN7

Gene Name:
GEMIN7
Gene Name:
79760
NCBI Accession:
NP_001007270
Primary Accession: Q9H840
Other Accession: NP_001007270
Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.