GFRα-4 rabbit polyclonal, anti-human, mouse, rat

Backgroud: The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for persephin, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for RET-associated diseases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008],alternative products:Additional isoforms seem to exist,function:Receptor for persephin. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. May be important in C-cell development and, in the postnatal development of the adrenal medulla.,similarity:Belongs to the GDNFR family.,tissue specificity:Predominantly expressed in the adult thyroid gland. Low levels also found in fetal adrenal and thyroid glands.,

Synonyms: GFRA4, GDNF family receptor alpha-4, GDNF receptor alpha-4, GDNFR-alpha-4, GFR-alpha-4, Persephin receptor

Gene Name: GFRA4

Gene ID: 64096

SwissProt ID: Q9GZZ7

Purification: Affinity purification

Storage: Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.