GFRA1 polyclonal, anti-human

Quantity: 100 µg

Background:
GDNF family receptor alpha-1 (GFRα1), also known as the GDNF receptor or GFRA1, is a protein that in humans is encoded by the GFRA1 gene. It is mapped to chromosome 10q25.3. The protein encoded by this gene is a member of the GDNF receptor family. GFRA1 is released by neuronal cells, Schwann cells, and injured sciatic nerve. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This gene is also a candidate gene for Hirschsprung disease. Soluble GFRA1 mediates robust recruitment of RET to lipid rafts via a mechanism requiring the RET tyrosine kinase.

Description:
Rabbit IgG polyclonal antibody for GDNF family receptor alpha-1 (GFRA1) detection. Tested with WB, IHC-P in Human.

Synonyms:
GDNF Family Receptor Alpha 1 antibody, GDNF R antibody, GDNF RA antibody, GDNF receptor alpha antibody, GDNFR alpha 1 antibody, GDNFR alpha antibody, GDNFR antibody, GDNFRA antibody, GDNFRalpha antibody, GFR alpha 1 antibody, GFR alpha1 antibody, GFR-ALPHA-1 antibody, GFRA 1 antibody, GFRA1 antibody, GFRalpha1 antibody, Glial Cell Line DErived Neurotrophic Factor Receptor Alpha antibody, Glial cell line-derived neurotrophic factor receptor alpha antibody, GPI linked anchor protein antibody, GPI-linked anchor protein antibody, MGC23045 antibody, PI linked cell surface accessory protein antibody, RET 1L antibody, RET ligand 1 antibody, RET1L antibody, RETL 1 antibody, RETL1 antibody, TGF beta related neurotrophic factor receptor 1 antibody, TGF-beta related neurotrophic factor receptor 1 antibody, TRNR 1 antibody, TRNR1 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
E.coli-derived human GFRA1 recombinant protein (Position: D25-Q227). Human GFRA1 shares 97% amino acid (aa) sequence identity with both mouse and rat GFRA1.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human

Applications: WB, IHC-P

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.