GFRA1 Polyclonal Antibody

Background:
Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for Hirschsprung disease. Multiple alternatively spliced transcript variants have been described for this gene.

Research Area: Cancer, Neuroscience

Synonyms:
GDNF family receptor alpha 1, GDNF family receptor alpha-1, GDNF R, GDNF RA, GDNF receptor alpha, GDNF receptor alpha-1, GDNFR alpha 1, GDNFR alpha, GDNFR, GDNFR-alpha-1, GDNFRA, GDNFRalpha, GFR alpha 1, GFR alpha1, GFR-alpha-1, GFRA 1, Gfra1, GFRA1, GFRalpha1, Glial cell line derived neurotrophic factor receptor alpha, GPI linked anchor protein, MGC23045, PI linked cell surface accessory protein, RET 1L, RET ligand 1, RET1L, RETL 1, RETL1, TGF beta related neurotrophic factor receptor 1, TGF-beta-related neurotrophic factor receptor 1, TRNR 1, TRNR1

Immunogen: Synthetic peptide of human GFRA1

Swissprot: P56159
Gene Accession: NP005255

Calculated MW: 51 kDa
Observed MW: Refer to figures

Purification Method: Antigen affinity purification

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Concentration: 1.92 mg/mL
Dilution: WB 1:500-1:2000, IHC 1:50-1:200, ELISA 1:5000-1:10000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.