GFRA2 polyclonal, anti-human, mouse, rat

Background:
Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This encoded protein acts preferentially as a receptor for NTN compared to its other family member, GDNF family receptor alpha 1. This gene is a candidate gene for RET-associated diseases. Multiple transcript variants encoding different isoforms have been found for this gene.

Synonyms: GDNFRB, NRTNR-ALPHA, NTNRA, RETL2, TRNR2

Cellular Location: Cell membrane GPI-anchor Lipid-anchor

Immunogen:
Recombinant protein of human GFRA2

Gene Symbol: GFRA2

Gene ID: 2675

Swiss prot: O00451

Calculated MW: 52kDa

Recommended dilution:
WB 1:200-2000

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.