GFRA2 Polyclonal Antibody

Background:
Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This encoded protein acts preferentially as a receptor for NTN compared to its other family member, GDNF family receptor alpha 1. This gene is a candidate gene for RET-associated diseases. Multiple transcript variants encoding different isoforms have been found for this gene.

Research Area: Cancer, Neuroscience

Synonyms:
GDNF family receptor alpha 2, GDNF family receptor alpha-2, GDNF receptor alpha-2, GDNF receptor beta, GDNFR beta, GDNFR-alpha-2, GDNFR-beta, GDNFRB, GFR alpha 2, GFR-alpha-2, GFRA 2, Gfra2, GFRA2, Glial cell line derived neurotrophic factor family receptor alpha2b, Glial cell line derived neurotrophic factor receptor beta, Neurturin receptor alpha, NRTNR alpha, NRTNR-alpha, NTNR alpha, NTNR-alpha, NTNRA, PI linked cell surface accessory protein, PI linked cell-surface accessory protein, RET ligand 2, RETL 2, RETL2, TGF beta related neurotrophic factor receptor 2, TGF-beta-related neurotrophic factor receptor 2, TRN receptor GPI anchored, TRNR 2, TRNR2

Immunogen: Synthetic peptide of human GFRA2

Swissprot: O00451
Gene Accession: NP001486

Calculated MW: 52 kDa
Observed MW: Refer to figures

Purification Method: Antigen affinity purification

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Concentration: 0.6 mg/mL
Dilution: WB 1:500-1:2000, ELISA 1:1000-1:2000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.