GGH polyclonal, anti-human, mouse
€388.00
In stock
SKU
BS71424
Background:
GGH (gamma-glutamyl hydrolase), also known as GH or Gamma-Glu-X carboxypeptidase, is a 318 amino acid protein that is secreted into the extracellular space and is also localized to both the lysosome and the melanosome. Functioning as a hydrolase, GGH contains one gamma-glutamyl hydrolase domain through which it catalyzes the hydrolysis of polyglutamate sidechains from pteroylpolyglutamates, specifically hydrolyzing gamma-glutamyl bonds. Via its catalytic activity, GGH may play a role in the bioavailability and metabolic activity of pteroylpolyglutamates. Polymorphisms in the gene encoding GGH are associated with rheumatoid arthritis, inflammatory bowel disease and various cancers.
Alternative Name:
Conjugase, GH, Gamma-Glu-X carboxypeptidase
Application Dilution: WB: 1:500 - 1:2000, IF: 1:50 - 1:100
Specificity: GGH polyclonal antibody detects endogenous levels of GGH protein.
Immunogen:
Recombinant protein of human GGH.
MW: ~ 36 kDa
Swis Prot.: Q92820
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
GGH (gamma-glutamyl hydrolase), also known as GH or Gamma-Glu-X carboxypeptidase, is a 318 amino acid protein that is secreted into the extracellular space and is also localized to both the lysosome and the melanosome. Functioning as a hydrolase, GGH contains one gamma-glutamyl hydrolase domain through which it catalyzes the hydrolysis of polyglutamate sidechains from pteroylpolyglutamates, specifically hydrolyzing gamma-glutamyl bonds. Via its catalytic activity, GGH may play a role in the bioavailability and metabolic activity of pteroylpolyglutamates. Polymorphisms in the gene encoding GGH are associated with rheumatoid arthritis, inflammatory bowel disease and various cancers.
Alternative Name:
Conjugase, GH, Gamma-Glu-X carboxypeptidase
Application Dilution: WB: 1:500 - 1:2000, IF: 1:50 - 1:100
Specificity: GGH polyclonal antibody detects endogenous levels of GGH protein.
Immunogen:
Recombinant protein of human GGH.
MW: ~ 36 kDa
Swis Prot.: Q92820
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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