GHR antibody (clone 3A12), anti-human
€435.00
In stock
SKU
AC-AT2198a
Catalog Number: AC-AT2198a
Size: 100 µg
Isotype: mouse IgG2a Kappa
Applications: WB, E
Request Information AC-AT2198a">Request Information
Size: 100 µg
Isotype: mouse IgG2a Kappa
Applications: WB, E
Request Information AC-AT2198a">Request Information
Background:
This gene encodes a protein that is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. A common alternate allele of this gene, called GHRd3, lacks exon three and has been well-characterized. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. Other splice variants, including one encoding a soluble form of the protein (GHRtr), have been observed but have not been thoroughly characterized. In humans and rabbits, but not rodents, growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain from the mature growth hormone receptor protein. The precise location of this cleavage site has not been determined for the human protein.
Other Names:
Growth hormone receptor, GH receptor, Somatotropin receptor, Growth hormone-binding protein, GH-binding protein, GHBP, Serum-binding protein, GHR
Antigen Type:
Recombinant Protein
Gene Name: GHR
Gene ID: 2690
NCBI Accession: NP_000154.1;NP_001229328.1;NP_001229329.1;NP_001229330.1;NP_001229331.1;NP_001229332.1;NP_001229333.1;NP_001229334.1;NP_001229335.1;NP_001229389.1;NP_001229391.1
Primary Accession: P10912
Other Accession: NM_000163
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
This gene encodes a protein that is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. A common alternate allele of this gene, called GHRd3, lacks exon three and has been well-characterized. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. Other splice variants, including one encoding a soluble form of the protein (GHRtr), have been observed but have not been thoroughly characterized. In humans and rabbits, but not rodents, growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain from the mature growth hormone receptor protein. The precise location of this cleavage site has not been determined for the human protein.
Other Names:
Growth hormone receptor, GH receptor, Somatotropin receptor, Growth hormone-binding protein, GH-binding protein, GHBP, Serum-binding protein, GHR
Antigen Type:
Recombinant Protein
Gene Name: GHR
Gene ID: 2690
NCBI Accession: NP_000154.1;NP_001229328.1;NP_001229329.1;NP_001229330.1;NP_001229331.1;NP_001229332.1;NP_001229333.1;NP_001229334.1;NP_001229335.1;NP_001229389.1;NP_001229391.1
Primary Accession: P10912
Other Accession: NM_000163
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
| Is Featured? | No |
|---|
Write Your Own Review