GHR Antibody (N-term) Blocking Peptide
€363.00
In stock
SKU
AC-BP16661a
Background:
This gene encodes a protein that is a transmembranereceptor for growth hormone. Binding of growth hormone to thereceptor leads to receptor dimerization and the activation of anintra- and intercellular signal transduction pathway leading togrowth. A common alternate allele of this gene, called GHRd3, lacksexon three and has been well-characterized. Mutations in this genehave been associated with Laron syndrome, also known as the growthhormone insensitivity syndrome (GHIS), a disorder characterized byshort stature. Other splice variants, including one encoding asoluble form of the protein (GHRtr), have been observed but havenot been thoroughly characterized. In humans and rabbits, but notrodents, growth hormone binding protein (GHBP) is generated byproteolytic cleavage of the extracellular ligand-binding domainfrom the mature growth hormone receptor protein. The preciselocation of this cleavage site has not been determined for thehuman protein.
Other Names:
Growth hormone receptor, GH receptor, Somatotropin receptor, Growth hormone-binding protein, GH-binding protein, GHBP, Serum-binding protein, GHR
Gene Name: GHR
Gene ID: 2690
Primary Accession: P10912
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
This gene encodes a protein that is a transmembranereceptor for growth hormone. Binding of growth hormone to thereceptor leads to receptor dimerization and the activation of anintra- and intercellular signal transduction pathway leading togrowth. A common alternate allele of this gene, called GHRd3, lacksexon three and has been well-characterized. Mutations in this genehave been associated with Laron syndrome, also known as the growthhormone insensitivity syndrome (GHIS), a disorder characterized byshort stature. Other splice variants, including one encoding asoluble form of the protein (GHRtr), have been observed but havenot been thoroughly characterized. In humans and rabbits, but notrodents, growth hormone binding protein (GHBP) is generated byproteolytic cleavage of the extracellular ligand-binding domainfrom the mature growth hormone receptor protein. The preciselocation of this cleavage site has not been determined for thehuman protein.
Other Names:
Growth hormone receptor, GH receptor, Somatotropin receptor, Growth hormone-binding protein, GH-binding protein, GHBP, Serum-binding protein, GHR
Gene Name: GHR
Gene ID: 2690
Primary Accession: P10912
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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