GHR polyclonal, anti-human, mouse, rat

Background:
GHR (growth hormone receptor) binds growth hormone (GH), which is produced by the anterior pituitary and regulates body growth and other metabolic processes. GHR is an integral membrane protein and a member of the cytokine receptor family. A common characteristic of the cytokine receptor family is having soluble forms of the protein. The soluble form of GHR is GH-binding protein (GHBP), which is generated by the proteolytic cleavage of the extracellular domain of GHR (2-4). Reduced levels of GHBP are associated with GH insensitivity syndrome (GHIS) (2,4). GHR has been shown to be transcribed via at least two different promoters, resulting in GHR 1A and GHR 1B. Both GHR 1A and 1B are expressed in liver, whereas GHR 1B is also expressed in muscle, uterus, and ovary tissues.

Alternative Name:
GH receptor, GH-binding protein, GHBP, GHR, GH receptor, GH-binding protein, GHBP, GHBP, included, GHR, GHR, Growth hormone binding protein, Growth hormone receptor, Growth hormone receptor precursor, Growth hormone-binding protein, Growth hormone-binding protein, included, Increased responsiveness to growth hormone, included, Serum binding protein, Serum-binding protein, Somatotropin receptor,

Application Dilution:
WB:1:500
ICC:1:50-1:200
IHC:1:50-1:200
FC:1:50-1:100

Specificity: Growth hormone receptor polyclonal antibody detects endogenous levels of Growth hormone receptor protein.

Immunogen:
Recombinant protein

MW: 71 kDa

Swiss-Prot: P10912(Human) P16882(Mouse) P16310(Rat)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.