GIT2 antibody (clone 3B5-B9), anti-human
€435.00
In stock
SKU
AC-AT2201a
Catalog Number: AC-AT2201a
Size: 100 µg
Isotype: mouse IgG2a Kappa
Applications: WB, IHC, IF
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Size: 100 µg
Isotype: mouse IgG2a Kappa
Applications: WB, IHC, IF
Request Information AC-AT2201a">Request Information
Background:
This gene encodes a member of the GIT protein family, which interact with G protein-coupled receptor kinases and possess ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity. GIT proteins traffic between cytoplasmic complexes, focal adhesions, and the cell periphery, and interact with Pak interacting exchange factor beta (PIX) to form large oligomeric complexes that transiently recruit other proteins. GIT proteins regulate cytoskeletal dynamics and participate in receptor internalization and membrane trafficking. This gene has been shown to repress lamellipodial extension and focal adhesion turnover, and is thought to regulate cell motility. This gene undergoes extensive alternative splicing to generate multiple isoforms, but the full-length nature of some of these variants has not been determined. The various isoforms have functional differences, with respect to ARF GAP activity and to G protein-coupled receptor kinase 2 binding.
Other Names:
ARF GTPase-activating protein GIT2, ARF GAP GIT2, Cool-interacting tyrosine-phosphorylated protein 2, CAT-2, CAT2, G protein-coupled receptor kinase-interactor 2, GRK-interacting protein 2, GIT2, KIAA0148
Antigen Type:
Recombinant Protein
Gene Name: GIT2
Gene ID: 9815
NCBI Accession: NP_001128685.1;NP_001128686.1;NP_055591.2;NP_476510.1;NP_476511.1
Primary Accession: Q14161
Other Accession: BC001379
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
This gene encodes a member of the GIT protein family, which interact with G protein-coupled receptor kinases and possess ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity. GIT proteins traffic between cytoplasmic complexes, focal adhesions, and the cell periphery, and interact with Pak interacting exchange factor beta (PIX) to form large oligomeric complexes that transiently recruit other proteins. GIT proteins regulate cytoskeletal dynamics and participate in receptor internalization and membrane trafficking. This gene has been shown to repress lamellipodial extension and focal adhesion turnover, and is thought to regulate cell motility. This gene undergoes extensive alternative splicing to generate multiple isoforms, but the full-length nature of some of these variants has not been determined. The various isoforms have functional differences, with respect to ARF GAP activity and to G protein-coupled receptor kinase 2 binding.
Other Names:
ARF GTPase-activating protein GIT2, ARF GAP GIT2, Cool-interacting tyrosine-phosphorylated protein 2, CAT-2, CAT2, G protein-coupled receptor kinase-interactor 2, GRK-interacting protein 2, GIT2, KIAA0148
Antigen Type:
Recombinant Protein
Gene Name: GIT2
Gene ID: 9815
NCBI Accession: NP_001128685.1;NP_001128686.1;NP_055591.2;NP_476510.1;NP_476511.1
Primary Accession: Q14161
Other Accession: BC001379
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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