GITR / Tnfrsf18 (mouse) (clone DTA-1 ), anti-mouse
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In stock
SKU
AC-AH12852
Catalog Number: AC-AH12852
Size: 20 µg, 100 µg
Isotype: Rat
Clone Name: DTA-1
Applications: IF, FC
Datasheet
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Size: 20 µg, 100 µg
Isotype: Rat
Clone Name: DTA-1
Applications: IF, FC
Datasheet
Request Information
Background:
GITR (glucocorticoid-induced TNFR-related gene) is a member of the TNF-receptor superfamily, also known as TNFRSF18. It is expressed at low levels on resting T lymphocytes and at high levels on CD25+ĀCD4+ĀTregs. The expression of GITR on T cells can be upregulated upon activation. Interaction of GITR with its ligand (GITRL) has been demonstrated to augment T cell activation, proliferation, cytokine production as well as MAPKs and NF-ĪŗB activation, and abrogate the inhibitory function ofĀCD25+ĀCD4+ĀTregs. In vivoĀactivation of GITR causes development of autoimmune diseases and restores the suppressed immune response.
Other Names:
Tumor necrosis factor receptor superfamily member 18, Glucocorticoid-induced TNFR-related protein, CD357, Tnfrsf18, Gitr
Gene Name: Tnfrsf18
Gene ID: 21936
Primary Accession: O35714
Other Accession: 21936 (Mouse), 3180 (Mouse), 482508 (Mouse)
GITR (glucocorticoid-induced TNFR-related gene) is a member of the TNF-receptor superfamily, also known as TNFRSF18. It is expressed at low levels on resting T lymphocytes and at high levels on CD25+ĀCD4+ĀTregs. The expression of GITR on T cells can be upregulated upon activation. Interaction of GITR with its ligand (GITRL) has been demonstrated to augment T cell activation, proliferation, cytokine production as well as MAPKs and NF-ĪŗB activation, and abrogate the inhibitory function ofĀCD25+ĀCD4+ĀTregs. In vivoĀactivation of GITR causes development of autoimmune diseases and restores the suppressed immune response.
Other Names:
Tumor necrosis factor receptor superfamily member 18, Glucocorticoid-induced TNFR-related protein, CD357, Tnfrsf18, Gitr
Gene Name: Tnfrsf18
Gene ID: 21936
Primary Accession: O35714
Other Accession: 21936 (Mouse), 3180 (Mouse), 482508 (Mouse)
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