GITR/TNFRSF18 Polyclonal Antibody

Background:
This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Synonyms:
TNFRSF18, AITR, CD357, GITR, GITR-D

Immunogen: Recombinant fusion protein of human GITR/TNFRSF18 (NP_683699.1).

Swissprot: Q9Y5U5
Gene ID: 8784

Calculated MW: 25 kDa/26 kDa
Observed MW: 30 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:500-1:2000"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.