GJB2 polyclonal (C-term), anti-human, mouse
€0.00
In stock
SKU
AC-AP1542a
Catalog Number: AC-AP1542a
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB1228
Applications: IHC-P, WB
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB1228
Applications: IHC-P, WB
Datasheet
Request Information
Background:
Gap junctions are conduits that allow the direct cell-to-cell passage of small cytoplasmic molecules, including ions, metabolic intermediates, and second messengers, and thereby mediate intercellular metabolic and electrical communication. Gap junction channels consist of connexin protein subunits, which are encoded by a multigene family. GJBs (gap-junction proteins or connexins) play crucial functional roles associated with these channels. Immunohistochemical staining of human cochlear cells demonstrated high levels of GJB2 expression. Mutations in GJB2 are associated with genetically derived hearing impairments, including autosomal recessive nonsyndromic deafness.
Other Names:
Gap junction beta-2 protein, Connexin-26, Cx26, GJB2
Target/Specificity:
This GJB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 204-226 amino acids from the C-terminal region of human GJB2.
Antigen Region:
204-226
Antigen Type: Synthetic Peptide
Gene Name: GJB2
Gene ID: 2706
Primary Accession: P29033
NCBI Accession: NP_003995.2
Other Accession: A2VE67; P46691
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Gap junctions are conduits that allow the direct cell-to-cell passage of small cytoplasmic molecules, including ions, metabolic intermediates, and second messengers, and thereby mediate intercellular metabolic and electrical communication. Gap junction channels consist of connexin protein subunits, which are encoded by a multigene family. GJBs (gap-junction proteins or connexins) play crucial functional roles associated with these channels. Immunohistochemical staining of human cochlear cells demonstrated high levels of GJB2 expression. Mutations in GJB2 are associated with genetically derived hearing impairments, including autosomal recessive nonsyndromic deafness.
Other Names:
Gap junction beta-2 protein, Connexin-26, Cx26, GJB2
Target/Specificity:
This GJB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 204-226 amino acids from the C-terminal region of human GJB2.
Antigen Region:
204-226
Antigen Type: Synthetic Peptide
Gene Name: GJB2
Gene ID: 2706
Primary Accession: P29033
NCBI Accession: NP_003995.2
Other Accession: A2VE67; P46691
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
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