Gli1 polyclonal, anti-human

Quantity: 100 µg

Background:
GLI1, also known as GLI, is a protein originally isolated in human glioblastoma. The protein is encoded by GLI1 gene. It is mapped to 12q13.3. This gene is a member of a select group of cellular genes that are genetically altered in primary human tumors. GLI1 encodes a member of the GLI-Kruppel family of zinc finger proteins in the final steps of Hedgehog signaling in normal development and disease. The encoded transcription factor is activated by the sonic hedgehog signal transduction cascade and regulates stem cell proliferation. The activity and nuclear localization of this protein is negatively regulated by p53 in an inhibitory loop. Beside, various upstream patterning signals may be integrated by the Gli proteins to direct a coherent programme of neurogenesis.

Description:
Rabbit IgG polyclonal antibody for Zinc finger protein GLI1 (GLI1) detection. Tested with WB, IHC-P in Human.

Synonyms:
Gli 1 antibody, GLI antibody, GLI family zinc finger 1 antibody, GLI Kruppel family member 1 antibody, gli1 antibody, GLI1_HUMAN antibody, Glioma associated oncogene 1 antibody, Glioma associated oncogene antibody, Glioma associated oncogene homolog 1 (zinc finger protein) antibody, Glioma associated oncogene homolog antibody, Glioma-associated oncogene antibody, Oncogene GLI antibody, Zfp 5 antibody, Zfp5 antibody, Zinc finger protein GLI 1 antibody, Zinc finger protein GLI1 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
E.coli-derived human GLi1 recombinant protein (Position: Q768-A1106). Human GLi1 shares 79% amino acid (aa) sequence identity with mouse GLi1.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human

Applications: WB, IHC-P

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500μg/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.