GLI2 polyclonal, anti-human, mouse

Background:
This gene encodes a protein which belongs to the C2H2-type zinc finger protein subclass of the Gli family. Members of this subclass are characterized as transcription factors which bind DNA through zinc finger motifs. These motifs contain conserved H-C links. Gli family zinc finger proteins are mediators of Sonic hedgehog (Shh) signaling and they are implicated as potent oncogenes in the embryonal carcinoma cell. The protein encoded by this gene localizes to the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also thought to play a role during embryogenesis. The encoded protein is associated with several phenotypes- Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, postaxial polydactyly types A1 and B.

Synonyms: CJS, HPE9, PHS2, THP1, THP2

Cellular Location: Nucleus

Immunogen:
A synthetic peptide of human GLI2

Gene Symbol: GLI2

Gene ID: 2736

Swiss prot: P10070

Calculated MW: 167 kDa/133 kDa/131 kDa/88 kDa/86 kDa

Recommended dilution:
IHC 1:30-150

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.