Glial Fibrillary Acidic Protein (GFAP) polyclonal, anti-human, bovine, rat

Quantity: 100 µl

Background:
This gene encodes one of the major intermediate filament proteins of mature astrocytes. It is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]

Synonyms:
GFAP

Isotype: Rabbit Polyclonal

Immunogen:
Isolated from human spinal cord

Form: Serum containing 0.1% sodium azide

Specificity:
The antibody is directed against the 56 kDa GFAP protein, the main intermediate filament of glial cells and astrocytes. The antibody can be used to discriminate glial tumors, including astrocytomas and ependymomas from other tumors, as meningiomas, neuroblastomas, chordomas, chondrosarcomas, lymphomas and carcinomas.

Reactivity: human, bovine, rat

Applications: Immunohistochemistry, suitable for frozen and paraffin sections (no proteolytic treatment required), Immunoblotting

Working DIlution: 1:25

Positive Control:
Brain tissue

Storage: 2-8C for immediate use, or at -20C (aliquot)

References:
- Perentes, E. et al. (1987) Arch Path Lab Med 111: 796-812