Glicentin/Glucagon polyclonal, anti-human, rat and pig

Quantity: 50 µl

Background:
The protein encoded by this gene is actually a preproprotein that is cleaved into four distinct mature peptides. One of these, glucagon, is a pancreatic hormone that counteracts the glucose-lowering action of insulin by stimulating glycogenolysis and gluconeogenesis. Glucagon is a ligand for a specific G-protein linked receptor whose signalling pathway controls cell proliferation. Two of the other peptides are secreted from gut endocrine cells and promote nutrient absorption through distinct mechanisms. Finally, the fourth peptide is similar to glicentin, an active enteroglucagon.

Synonyms:
GCG, GLP1, GLP2, GRPP

Isotype: Rabbit Polyclonal

Immunogen:
Porcine pancreatic glucagons conjugated to BSA

Form: Serum containing 0.1% sodium azide

Specificity:
This glicentin antibody is reactive with glicentin as well as glucagons. The antibody can be used for the diagnosis of tumors from the distal intestine (rectal carcinoids) as well as pancreatic islet cell tumors.

Reactivity: human, rat and pig

Applications: Immunohistochemistry, suitable for frozen and paraffin-embedded tissue (no protease pretreatment required)

Working DIlution: 1:50 in immunohistochemistry

Positive Control:
Pancreas, small intestine

Storage: 2-8C for immediate use, or at -20C (aliquot)

References:
- Myrserin U et al. (1996) Diabetes 45: 1306-1313