GLIS2 Antibody (Center) Blocking Peptide
€363.00
In stock
SKU
AC-BP16510c
Background:
This gene is a member of the GLI-similar zinc fingerprotein family and encodes a nuclear transcription factor with fiveC2H2-type zinc finger domains. The protein encoded by this gene iswidely expressed at low levels in the neural tube and peripheralnervous system and likely promotes neuronal differentiation. It isabundantly expressed in the kidney and may have a role in theregulation of kidney morphogenesis. p120 regulates the expressionlevel of this protein and induces the cleavage of this protein'sC-terminal zinc finger domain. This protein also promotes thenuclear translocation of p120. Mutations in this gene causenephronophthisis (NPHP), an autosomal recessive kidney diseasecharacterized by tubular basement membrane disruption, interstitiallymphohistiocytic cell infiltration, and development of cysts atthe corticomedullary border of the kidneys.
Other Names:
Zinc finger protein GLIS2, GLI-similar 2, Neuronal Krueppel-like protein, GLIS2, NKL
Gene Name: GLIS2
Gene ID: 84662
Primary Accession: Q9BZE0
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
This gene is a member of the GLI-similar zinc fingerprotein family and encodes a nuclear transcription factor with fiveC2H2-type zinc finger domains. The protein encoded by this gene iswidely expressed at low levels in the neural tube and peripheralnervous system and likely promotes neuronal differentiation. It isabundantly expressed in the kidney and may have a role in theregulation of kidney morphogenesis. p120 regulates the expressionlevel of this protein and induces the cleavage of this protein'sC-terminal zinc finger domain. This protein also promotes thenuclear translocation of p120. Mutations in this gene causenephronophthisis (NPHP), an autosomal recessive kidney diseasecharacterized by tubular basement membrane disruption, interstitiallymphohistiocytic cell infiltration, and development of cysts atthe corticomedullary border of the kidneys.
Other Names:
Zinc finger protein GLIS2, GLI-similar 2, Neuronal Krueppel-like protein, GLIS2, NKL
Gene Name: GLIS2
Gene ID: 84662
Primary Accession: Q9BZE0
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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