GLIS2 polyclonal (Center), anti-human
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In stock
SKU
AC-AP16510c
Catalog Number: AC-AP16510c
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB35978
Applications: WB
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB35978
Applications: WB
Datasheet
Request Information
Background:
This gene is a member of the GLI-similar zinc finger protein family and encodes a nuclear transcription factor with five C2H2-type zinc finger domains. The protein encoded by this gene is widely expressed at low levels in the neural tube and peripheral nervous system and likely promotes neuronal differentiation. It is abundantly expressed in the kidney and may have a role in the regulation of kidney morphogenesis. p120 regulates the expression level of this protein and induces the cleavage of this protein's C-terminal zinc finger domain. This protein also promotes the nuclear translocation of p120. Mutations in this gene cause nephronophthisis (NPHP), an autosomal recessive kidney disease characterized by tubular basement membrane disruption, interstitial lymphohistiocytic cell infiltration, and development of cysts at the corticomedullary border of the kidneys.
Other Names:
Zinc finger protein GLIS2, GLI-similar 2, Neuronal Krueppel-like protein, GLIS2, NKL
Target/Specificity:
This GLIS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 173-202 amino acids from the Central region of human GLIS2.
Antigen Region:
173-202
Antigen Type: Synthetic Peptide
Gene Name: GLIS2
Gene ID: 84662
Primary Accession: Q9BZE0
NCBI Accession: NP_115964.2
Other Accession: NP_115964.2
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
This gene is a member of the GLI-similar zinc finger protein family and encodes a nuclear transcription factor with five C2H2-type zinc finger domains. The protein encoded by this gene is widely expressed at low levels in the neural tube and peripheral nervous system and likely promotes neuronal differentiation. It is abundantly expressed in the kidney and may have a role in the regulation of kidney morphogenesis. p120 regulates the expression level of this protein and induces the cleavage of this protein's C-terminal zinc finger domain. This protein also promotes the nuclear translocation of p120. Mutations in this gene cause nephronophthisis (NPHP), an autosomal recessive kidney disease characterized by tubular basement membrane disruption, interstitial lymphohistiocytic cell infiltration, and development of cysts at the corticomedullary border of the kidneys.
Other Names:
Zinc finger protein GLIS2, GLI-similar 2, Neuronal Krueppel-like protein, GLIS2, NKL
Target/Specificity:
This GLIS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 173-202 amino acids from the Central region of human GLIS2.
Antigen Region:
173-202
Antigen Type: Synthetic Peptide
Gene Name: GLIS2
Gene ID: 84662
Primary Accession: Q9BZE0
NCBI Accession: NP_115964.2
Other Accession: NP_115964.2
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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