GLK polyclonal, anti-human, mouse, rat
€388.00
In stock
SKU
BS8854
Background:
Several mammalian kinases have been identified which exhibit sequence similarity to the Saccharomyces cerevisiae serine/threonine kinase STE20. STE20 is involved in relaying signals from G-protein coupled receptors to cytosolic MAP kinase cascades, and it lies upstream of a MAP kinase kinase kinase. Mammalian STE20-like kinases include GLK, KHS, NIK, YSK1, HPK1, Krs-1, Krs-2 and human GC kinase. GLK (for GC-like kinase) is an 885 amino acid protein that shares a high degree of homology with GC kinase and HPK1. Like many of the STE20-like kinases, GLK specifically activates the JNK pathway. Epistasis studies with dominant negative mutants of MEKK1 suggest that GLK functions upstream of MEKK1 in the JNK signaling pathway.
Alternative Name:
Mitogen-activated protein kinase kinase kinase kinase 3, MAPK/ERK kinase kinase kinase 3, MEK kinase kinase 3, Germinal center kinase related protein kinase, MEKKK 3, MAP4K3
Application Dilution: WB: 1:500~1:2000, IHC: 1:50~1:200
Specificity: GLK polyclonal antibody detects endogenous levels of GLK protein.
Immunogen:
Recombinant full length Human GLK.
MW: ~ 101kDa
Swis Prot.: Q8IVH8
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Several mammalian kinases have been identified which exhibit sequence similarity to the Saccharomyces cerevisiae serine/threonine kinase STE20. STE20 is involved in relaying signals from G-protein coupled receptors to cytosolic MAP kinase cascades, and it lies upstream of a MAP kinase kinase kinase. Mammalian STE20-like kinases include GLK, KHS, NIK, YSK1, HPK1, Krs-1, Krs-2 and human GC kinase. GLK (for GC-like kinase) is an 885 amino acid protein that shares a high degree of homology with GC kinase and HPK1. Like many of the STE20-like kinases, GLK specifically activates the JNK pathway. Epistasis studies with dominant negative mutants of MEKK1 suggest that GLK functions upstream of MEKK1 in the JNK signaling pathway.
Alternative Name:
Mitogen-activated protein kinase kinase kinase kinase 3, MAPK/ERK kinase kinase kinase 3, MEK kinase kinase 3, Germinal center kinase related protein kinase, MEKKK 3, MAP4K3
Application Dilution: WB: 1:500~1:2000, IHC: 1:50~1:200
Specificity: GLK polyclonal antibody detects endogenous levels of GLK protein.
Immunogen:
Recombinant full length Human GLK.
MW: ~ 101kDa
Swis Prot.: Q8IVH8
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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