GLO1 polyclonal, anti-human, mouse, rat

Background:
The glyoxal pathway plays a role in the detoxification of glucose degradation products (GDP). Glyoxalase I (GLO1), a member of the glyoxalase family, is effective in eliminating GDP. Overexpression or silencing of Glyoxalase I in mice brain suggests an association between Glyoxalase I and anxiety. Glyoxalase I has three isoforms generated from two alleles in the genome which forms two homodimers and one heterodimer, each subunit binding one zinc ion. Research demonstrates that GLO1 gene expression is induced in colon carcinoma. Both an insulin response element (IRE), and a zinc metal response element (MRE) in the promoter region of the GLO1 gene have been identified.

Alternative Name:
Glx I, GLO1, Aldoketomutase, glo1, GLOD1, Glx I, GLYI, glyoxalase domain containing 1, Glyoxalase I, Ketone aldehyde mutase, Ketone-aldehyde mutase, Lactoyl glutathione lyase, Lactoylglutathione lyase, LGUL, Methylglyoxalase, S D lactoylglutathione methylglyoxal lyase, S-D-lactoylglutathione methylglyoxal lyase,

Application Dilution:
WB:1:500-1:2,000
ICC:1:100-1:500
IHC:1:100-1:500
FC:1:50-1:100

Specificity: GLO1 polyclonal antibody detects endogenous levels of GLO1 protein.

Immunogen:
Recombinant protein

MW: 21 kDa

Swiss-Prot: Q04760(Human) Q9CPU0(Mouse) Q6P7Q4(Rat)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.