Glucagon [19-29] Peptide
€137.00
In stock
SKU
350201
Protein Family: Hormones
Pathway and Disease: Carbohydrate Metabolism, Endocrine System, Energy Metabolism, Metabolic Disorders, Signaling Molecules and Interaction
Alternate Names: Miniglucagon; Glucagon; GCG; CAS 64790-15-4; Glucagon (19-29)
Accession No.: P01275
Description:
Glucagon [19-29] corresponds to the C-terminal fragment of glucagon, a hormone secreted in the A cells of the islets of Langherans that plays a key role in glucose metabolism and homeostasis. Glucagon [19-29] is a potent Ca2+/Mg2+-ATPase inhibitor. It inhibits secretagogue-induced insulin secretion in beta-cells (IC50<1 pM) and Ca2+/Mg2+-ATPase activity in liver plasma membranes (IC50=0.75 nM). It also contributes to the positive inotropic effect of glucagon in cardiac cells by amplifying the cytosolic Ca2+ signal.
Format:
Each vial contains 2 mg of lyophilized solid packaged under an inert gas and supplied as a trifluoroacetate salt.
MW: 1352.54 g/mol
Sequence:
Human: H-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr-OH or H-AQDFVQWLMNT-OH
Composition:
C61H89N15O18S1
Purity:
> 95% by HPLC
Solubility:
Distilled water for a solution up to 2 mg/ml, otherwise we recommend using acetonitrile.
Storage:
Store at -20°C. The product is hygroscopic and must be protected from light. Product is guaranteed one year from the date of shipment. Following reconstitution, aliquot and store at -20°C.
Pathway and Disease: Carbohydrate Metabolism, Endocrine System, Energy Metabolism, Metabolic Disorders, Signaling Molecules and Interaction
Alternate Names: Miniglucagon; Glucagon; GCG; CAS 64790-15-4; Glucagon (19-29)
Accession No.: P01275
Description:
Glucagon [19-29] corresponds to the C-terminal fragment of glucagon, a hormone secreted in the A cells of the islets of Langherans that plays a key role in glucose metabolism and homeostasis. Glucagon [19-29] is a potent Ca2+/Mg2+-ATPase inhibitor. It inhibits secretagogue-induced insulin secretion in beta-cells (IC50<1 pM) and Ca2+/Mg2+-ATPase activity in liver plasma membranes (IC50=0.75 nM). It also contributes to the positive inotropic effect of glucagon in cardiac cells by amplifying the cytosolic Ca2+ signal.
Format:
Each vial contains 2 mg of lyophilized solid packaged under an inert gas and supplied as a trifluoroacetate salt.
MW: 1352.54 g/mol
Sequence:
Human: H-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr-OH or H-AQDFVQWLMNT-OH
Composition:
C61H89N15O18S1
Purity:
> 95% by HPLC
Solubility:
Distilled water for a solution up to 2 mg/ml, otherwise we recommend using acetonitrile.
Storage:
Store at -20°C. The product is hygroscopic and must be protected from light. Product is guaranteed one year from the date of shipment. Following reconstitution, aliquot and store at -20°C.
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