Glucagon-Like Peptide 1 [7-37] Peptide

Protein Family: Receptors and Channels

Pathway and Disease: Signaling molecules and interaction

Alternate Names: Glucagon-like peptide 1 (7-37); GLP-1 (7-37); Glucagon; GCG

Accession No.: P01275

Description:
Glucagon-like peptide 1 (GLP-1) is a potent stimulator of glucose-dependent insulin release and plays important roles on gastric motility and the suppression of plasma glucagon levels. Glucagon, secreted in the A cells of the islets of Langherans, plays a key role in glucose metabolism and homeostasis. Proglucagon is processed in glucagon, GLP-1, GLP-2, glicentin and oxyntomodulin depending on tissue. Glucagon is used to treat severe hypoglycemia in insulin-dependent diabetics under the names Glucagon (Eli Lilly) and GlucaGen or Glucagon Novo Nordisk (Novo Nordisk).

Format:
Each vial contains 1 mg of lyophilized solid packaged under an inert gas and supplied as a trifluoroacetate salt.

MW: 3337.73 g/mol

Sequence:
H-His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-Gly-OH or H-HAEGTFTSDVSSYLEGQAAKEFIAWLVKGRG-OH

Composition:
C151H226N40O46

Purity:
> 95% by HPLC

Solubility:
Distilled water for a solution up to 2 mg/ml, otherwise we recommend using acetonitrile.

Storage:
Store at -20°C. The product is hygroscopic and must be protected from light. Product is guaranteed one year from the date of shipment. Following reconstitution, aliquot and store at -20°C.